产品货号：
Z19496
中文名称：
KU80/XRCC5抗体
英文名称：
Anti-KU80/XRCC5 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-KU80/XRCC5 Antibody |
| 指标别名 | 86kDa subunit of Ku antigen;CTC85;CTCBF;DNA repair protein XRCC5;G22P2;KARP 1;KARP1;Ku80;Ku86;KUB2;NFIV;Nuclear factor IV;Thyroid lupus autoantigen;TLAA;XRCC5;XRCC5/Ku80 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,IF,ICC/IF,FCM |
| 基因名称 | XRCC5 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human Ku80(648-662aa KFSEEQRFNNFLKAL). |
| 实际分子量 | 83KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | XRCC5(X-ray Repair,Complementing Defective,In Chinese Hamster,5),also known as Ku80 or Ku86,is a protein that in humans,is encoded by the XRCC5 gene.The XRCC5 gene encodes the 80-kD subunit of the Ku autoantigen,a heterodimer which contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologous end joining(NHEJ) pathway.The XRCC5 gene is mapped to 2q35.Human colon cancer cells heterozygous for Ku86 are haploinsufficient with an increase in polyploid cells,a reduction in cell proliferation,elevated p53 levels,and a slight hypersensitivity to ionizing radiation.Functional inactivation of the second Ku86 allele results in cells with a drastically reduced doubling time.The Ku86 locus is essential in human somatic tissue culture cells by experiments demonstration.A rare microsatellite polymorphism in XRCC5 is associated with cancer in patients of varying radiosensitivity. |
| Uniprot ID | P13010 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | X-ray repair complementing defective repair in Chinese hamster cells 5(double-strand-break rejoining) |
| 蛋白名全称 | X-ray repair cross-complementing protein 5 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunofluorescence (IF) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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